Volume 5 Supplement 1

Selected articles from the 4th International Conference on Computational Systems Biology (ISB 2010)

Reports

Edited by Luonan Chen, Xiang-Sun Zhang and Yong Wang

The 4th International Conference on Computational Systems Biology (ISB 2010). Go to conference site.

Suzhou, P. R. China

9-11 September 2010

  1. Report

    Functional pathway mapping analysis for hypoxia-inducible factors

    Hypoxia-inducible factors (HIFs) are transcription factors that play a crucial role in response to hypoxic stress in living organisms. The HIF pathway is activated by changes in cellular oxygen levels and has ...

    Chia-Sheng Chuang, Tun-Wen Pai, Chin-Hua Hu, Wen-Shyong Tzou, Margaret Dah-Tsyr Chang, Hao-Teng Chang and Chih-Chia Chen

    BMC Systems Biology 2011 5(Suppl 1):S3

    Published on: 20 June 2011

  2. Report

    Regulatory link mapping between organisms

    Identification of gene regulatory networks is useful in understanding gene regulation in any organism. Some regulatory network information has already been determined experimentally for model organisms, but mu...

    Rachita Sharma, Patricia A Evans and Virendrakumar C Bhavsar

    BMC Systems Biology 2011 5(Suppl 1):S4

    Published on: 20 June 2011

  3. Report

    MetaDBSite: a meta approach to improve protein DNA-binding sites prediction

    Protein-DNA interactions play an important role in many fundamental biological activities such as DNA replication, transcription and repair. Identification of amino acid residues involved in DNA binding site i...

    Jingna Si, Zengming Zhang, Biaoyang Lin, Michael Schroeder and Bingding Huang

    BMC Systems Biology 2011 5(Suppl 1):S7

    Published on: 20 June 2011

  4. Report

    Integrating multiple types of data to predict novel cell cycle-related genes

    Cellular functions depend on genetic, physical and other types of interactions. As such, derived interaction networks can be utilized to discover novel genes involved in specific biological processes. Epistati...

    Lin Wang, Lin Hou, Minping Qian, Fangting Li and Minghua Deng

    BMC Systems Biology 2011 5(Suppl 1):S9

    Published on: 20 June 2011

  5. Report

    An improved kinetic model for the acetone-butanol-ethanol pathway of Clostridium acetobutylicum and model-based perturbation analysis

    Comprehensive kinetic models of microbial metabolism can enhance the understanding of system dynamics and regulatory mechanisms, which is helpful in optimizing microbial production of industrial chemicals. Clostr...

    Ru-Dong Li, Yuan-Yuan Li, Ling-Yi Lu, Cong Ren, Yi-Xue Li and Lei Liu

    BMC Systems Biology 2011 5(Suppl 1):S12

    Published on: 20 June 2011

  6. Report

    A trigger model of apoptosis induced by tumor necrosis factor signaling

    The ability of living cells to respond appropriately to apoptosis signals is crucial for the proper development and homeostasis of multicellular organisms. For example, viable cells must be stable enough to ap...

    Chang Gu, Junjie Zhang, Yingyu Chen and Jinzhi Lei

    BMC Systems Biology 2011 5(Suppl 1):S13

    Published on: 20 June 2011

  7. Report

    Multi-equilibrium property of metabolic networks: SSI module

    Revealing the multi-equilibrium property of a metabolic network is a fundamental and important topic in systems biology. Due to the complexity of the metabolic network, it is generally a difficult task to stud...

    Hong-Bo Lei, Ji-Feng Zhang and Luonan Chen

    BMC Systems Biology 2011 5(Suppl 1):S15

    Published on: 20 June 2011

  8. Report

    Possible linkages between the inner and outer cellular states of human induced pluripotent stem cells

    Human iPS cells (hiPSCs) have attracted considerable attention for applications to drug screening and analyses of disease mechanisms, and even as next generation materials for regenerative medicine. Genetic re...

    Shigeru Saito, Yasuko Onuma, Yuzuru Ito, Hiroaki Tateno, Masashi Toyoda, Akutsu Hidenori, Koichiro Nishino, Emi Chikazawa, Yoshihiro Fukawatase, Yoshitaka Miyagawa, Hajime Okita, Nobutaka Kiyokawa, Yohichi Shimma, Akihiro Umezawa, Jun Hirabayashi, Katsuhisa Horimoto…

    BMC Systems Biology 2011 5(Suppl 1):S17

    Published on: 20 June 2011