Volume 8 Supplement 2

Selected articles from the High-Throughput Omics and Data Integration Workshop


Edited by David Gomez-Cabrero, Ana Conesa, Jesper Tegner, Dieter Maier, Matthias Merkenschlager, Imad Abugessaisa, Andreas Gisel, Erik Bongcam-Rudloff, Esteban Ballestar and Andrew Teschendorff

Publication of this supplement has been partially funded by COST-BMBS, Action BM1006 "Next Generation Sequencing Data Analysis Network", SeqAhead. Information about the source of funding for the remaining publication charges can be found in the individual articles. Articles have undergone the journal's standard review process for supplements. The Supplement Editors declare that they have no competing interests.

High-Throughput Omics and Data Integration Workshop. Go to conference site.

Barcelona, Spain

13-15 February 2013

  1. Introduction

    Data integration in the era of omics: current and future challenges

    To integrate heterogeneous and large omics data constitutes not only a conceptual challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel omics technologies and through lar...

    David Gomez-Cabrero, Imad Abugessaisa, Dieter Maier, Andrew Teschendorff, Matthias Merkenschlager, Andreas Gisel, Esteban Ballestar, Erik Bongcam-Rudloff, Ana Conesa and Jesper Tegnér

    BMC Systems Biology 2014 8(Suppl 2):I1

    Published on: 13 March 2014

  2. Review

    The common ground of genomics and systems biology

    The rise of systems biology is intertwined with that of genomics, yet their primordial relationship to one another is ill-defined. We discuss how the growth of genomics provided a critical boost to the popular...

    Ana Conesa and Ali Mortazavi

    BMC Systems Biology 2014 8(Suppl 2):S1

    Published on: 13 March 2014

  3. Review

    Bioinformatic analysis of proteomics data

    Most biochemical reactions in a cell are regulated by highly specialized proteins, which are the prime mediators of the cellular phenotype. Therefore the identification, quantitation and characterization of al...

    Andreas Schmidt, Ignasi Forne and Axel Imhof

    BMC Systems Biology 2014 8(Suppl 2):S3

    Published on: 13 March 2014

  4. Research

    Kernel-PCA data integration with enhanced interpretability

    Nowadays, combining the different sources of information to improve the biological knowledge available is a challenge in bioinformatics. One of the most powerful methods for integrating heterogeneous data type...

    Ferran Reverter, Esteban Vegas and Josep M Oller

    BMC Systems Biology 2014 8(Suppl 2):S6

    Published on: 13 March 2014

  5. Research

    Pathway network inference from gene expression data

    The development of high-throughput omics technologies enabled genome-wide measurements of the activity of cellular elements and provides the analytical resources for the progress of the Systems Biology discipl...

    Ignacio Ponzoni, María José Nueda, Sonia Tarazona, Stefan Götz, David Montaner, Julieta Sol Dussaut, Joaquín Dopazo and Ana Conesa

    BMC Systems Biology 2014 8(Suppl 2):S7

    Published on: 13 March 2014

  6. Research

    A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease

    An important step toward understanding the biological mechanisms underlying a complex disease is a refined understanding of its clinical heterogeneity. Relating clinical and molecular differences may allow us ...

    Jörg Menche, Amitabh Sharma, Michael H Cho, Ruth J Mayer, Stephen I Rennard, Bartolome Celli, Bruce E Miller, Nick Locantore, Ruth Tal-Singer, Soumitra Ghosh, Chris Larminie, Glyn Bradley, John H Riley, Alvar Agusti, Edwin K Silverman and Albert-László Barabási

    BMC Systems Biology 2014 8(Suppl 2):S8

    Published on: 13 March 2014

  7. Research

    STATegra EMS: an Experiment Management System for complex next-generation omics experiments

    High-throughput sequencing assays are now routinely used to study different aspects of genome organization. As decreasing costs and widespread availability of sequencing enable more laboratories to use sequenc...

    Rafael Hernández-de-Diego, Noemi Boix-Chova, David Gómez-Cabrero, Jesper Tegner, Imad Abugessaisa and Ana Conesa

    BMC Systems Biology 2014 8(Suppl 2):S9

    Published on: 13 March 2014