Figure 1

Network of protein and gene interactions as derived from different theoretical and computational approaches. Light blue lines connect genes that co-occur in papers, as determined using iHOP. Mauve lines connect genes that have a significant phylogenetic coincidence, as measured by both the mutual information and the transformed Hamming distance index we use. Yellow lines connect proteins that have either been experimentally reported to interact or have been predicted in this work via in silico protein docking as being more likely to interact. Dark blue lines connect genes that co-occur in the literature and have a significant Phylogenetic coincidence. Green lines connect genes/proteins that co-occur in the literature and have been predicted to interact by our in silico docking experiments. Red lines connect genes/proteins that have a significant Phylogenetic coincidence and are predicted to interact by our docking experiments. Black lines connect genes/proteins that co-occur in the literature, have a significant Phylogenetic conservation and have been predicted to interact by the docking experiments.