The influence of hidden variables. (a) Transcriptional-regulatory network as given in . Nodes correspond to genes. Solid lines indicate transcriptional regulation, dashed lines represent interactions between proteins. (b) Connectivity of the observed mRNA variables. The network is constructed from the Jacobian matrix of the system of ODEs given by . (c) mRNA interaction network reconstructed from KO time series of all 10 genes; each time series contributes 10 data points per gene. MCMC simulations are used to calculate mRNA-mRNA interaction probabilities. Only interactions with a posterior probability ≥ 0.5 are depicted.