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Figure 9 | BMC Systems Biology

Figure 9

From: Dynamics of in silico leukocyte rolling, activation, and adhesion

Figure 9

Comparison of in vitro and in silico results for six different experimental conditions. The in vitro conditions (from [3]): the flow chamber surface was coated with P-selectin and/or VCAM-1 with or without immobilized GRO-α chemokine. The number of leukocytes that rolled and adhered within each of five fields of view were recorded for a 30-second observation interval. In vitro: white circles: average number of leukocytes that rolled; white squares: average number of leukocytes that adhered; error bars: ± 1 SD. The data are clustered and plotted for each of six conditions, as labeled. By using the parameter values in Table 5 (part III), the in silico experiments mimicked the in vitro experimental conditions and also the results: the results are averages from 20 sets containing 30 LEUKOCYTES each; each simulation ran for 300 simulation cycles (equivalent to about 30 seconds). In silico: dark circles: average LEUKOCYTES that ROLLED; dark squares: average LEUKOCYTES that ADHERED; error bars: ± 1 SD. Each light gray box contains the two sets of observations (in vitro and in silico) that should be compared.

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