Figure 4

Gene expression components of the phenotypic prototypes. Plotting of the gene expression component of the prototypes from the clusters generated from clustering the acetaminophen data using the modk-prototypes algorithm (with the levels of the necrosis of the centrilobular region of the rat liver included, 100 iterations and the average of the suggested weights of the domain data). a) All genes detected as significantly differentially expressed b) 82 genes significant and unique in distinguishing contrasts between the levels of necrosis of the centrilobular region of the rat liver. The red, blue and green lines denote the gene expression prototype from Clusters 1, 2 and 3 respectively. The log₁₀ ratio values of the genes from the prototypes are signified on the y axis and the indices for the genes are denoted on the x axis.