The numbers in paranthesis shows EFM numbers when the biomass composition of  is employed for comparison. EFM numbers for a smaller model (M57) are also given for comparison. The larger model (M81) includes 81 reactions and contains part of the amino acid biosynthesis together with the central carbon metabolism. The smaller model only covers the central metabolism with 57 reactions. *In M81, the EFMs with simultaneous occurrence of GDH2 and GDH13 were not taken into account since this leads to transhdrogenase activity, which is known to be not available in S. cerevisiae.