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Figure 1 | BMC Systems Biology

Figure 1

From: Including metabolite concentrations into flux balance analysis: thermodynamic realizability as a constraint on flux distributions in metabolic networks

Figure 1

Penalty score for concentration values. Illustration of the penalty score used in the objective function to incorporate constraints to metabolite concentrations. The x-axis refers to logarithmic concentration values of the metabolite. If the concentration value coincides with the set-point value the penalty score is zero. For concentration values lying within the soft bounds the score depends quadratically on the distance from the set-point value. For concentration values lying outside the soft bounds the score increases linearly with increasing distance from the adjacent soft bound. Concentration values outside the hard bounds are forbidden as indicated by the truncated line.

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