Skip to main content

Table 7 Mapping the HCR sets to the drug targets described by Mdluli and Spigelman [39]. The first column includes the protein names (adopted from Mdluli and Spigelman), the second column lists the corresponding gene locus, the third is the HCR set number and the fourth lists how many reactions are in the HCR set. Only those drug targets mapped to an HCR are shown. [See Additional file 3] for the full set of HCR sets and the individual reactions they are comprised of; the HCR sets mapped to the above drug targets are highlighted in these data.

From: Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ 661 and proposing alternative drug targets

HCRs mapped to Mtb drug targets

Drug Target

Gene Locus

HCR

HCR size

EmbA

Rv3794

43

10

EmbB

Rv3795

43

10

EmbC

Rv3793

43

10

AftA

Rv3792

43

10

decaprenyl phosphoryltransferase

Rv3806c

62

3

udp galatofuraosyltransferase

Rv3808c

43

10

dTDP-deoxy-hexulose reductase

Rv3809c

43

10

RmlA

Rv0334

69

4

RmlB

Rv3464

69

4

RmlC

Rv3465

69

4

RmbD

Rv3266c

69

4

InhA

Rv1484

57

3

MabA

Rv1483

90

5

KasA

Rv2245

90

5

KasB

Rv2246

90

5

MmaA4

Rv0642c

93

4

Pks13

Rv3800c

86

4

FadD32

Rv3801c

86

4

AccD5

Rv3280

78

2

LeuD

Rv2987c

14

2

TrpD

Rv2192c

10

4

DapB

Rv2773c

2

3

AroA

Rv3227

20

3

AroC

Rv2540c

20

3

AroE

Rv2537c

11

4

AroG

Rv2178c

11

4

AroQ

Rv2537c

11

4

ilvG (acetolactate synthase)

Rv1820

3

3

ilvX (acetolactate synthase)

Rv3509c

3

3

ilvN (acetolactate synthase)

Rv3002c

3

3

ilvB (acetolactate synthase)

Rv3003c

3

3

ilvB2 (acetolactate synthase)

Rv3470c

3

3

branchd chain aminotransferase

Rv2210c

84

2

dihyropteroate synthase

Rv3608c

9

3

dihyropteroate synthase

Rv1207

9

3

PanC

Rv3602c

12

4

riboflavin synthase

Rv1416

56

3

riboflavin synthase

Rv1412

56

3

sulfotransferase

Rv1373

131

2

MshA

Rv0486

80

2

MshB

Rv1170

80

2

MshC

Rv2130c

50

2

MshD

Rv0819

50

2

IspD

Rv3582c

16

5

IspE

Rv1011

16

5

IspF

Rv3581c

16

5

MenA

Rv0534c

13

2

MenB

Rv0548c

122

3

MenD

Rv0555

125

2

MenE

Rv0542c

122

3