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Table 7 Mapping the HCR sets to the drug targets described by Mdluli and Spigelman [39]. The first column includes the protein names (adopted from Mdluli and Spigelman), the second column lists the corresponding gene locus, the third is the HCR set number and the fourth lists how many reactions are in the HCR set. Only those drug targets mapped to an HCR are shown. [See Additional file 3] for the full set of HCR sets and the individual reactions they are comprised of; the HCR sets mapped to the above drug targets are highlighted in these data.

From: Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ 661 and proposing alternative drug targets

HCRs mapped to Mtb drug targets
Drug Target Gene Locus HCR HCR size
EmbA Rv3794 43 10
EmbB Rv3795 43 10
EmbC Rv3793 43 10
AftA Rv3792 43 10
decaprenyl phosphoryltransferase Rv3806c 62 3
udp galatofuraosyltransferase Rv3808c 43 10
dTDP-deoxy-hexulose reductase Rv3809c 43 10
RmlA Rv0334 69 4
RmlB Rv3464 69 4
RmlC Rv3465 69 4
RmbD Rv3266c 69 4
InhA Rv1484 57 3
MabA Rv1483 90 5
KasA Rv2245 90 5
KasB Rv2246 90 5
MmaA4 Rv0642c 93 4
Pks13 Rv3800c 86 4
FadD32 Rv3801c 86 4
AccD5 Rv3280 78 2
LeuD Rv2987c 14 2
TrpD Rv2192c 10 4
DapB Rv2773c 2 3
AroA Rv3227 20 3
AroC Rv2540c 20 3
AroE Rv2537c 11 4
AroG Rv2178c 11 4
AroQ Rv2537c 11 4
ilvG (acetolactate synthase) Rv1820 3 3
ilvX (acetolactate synthase) Rv3509c 3 3
ilvN (acetolactate synthase) Rv3002c 3 3
ilvB (acetolactate synthase) Rv3003c 3 3
ilvB2 (acetolactate synthase) Rv3470c 3 3
branchd chain aminotransferase Rv2210c 84 2
dihyropteroate synthase Rv3608c 9 3
dihyropteroate synthase Rv1207 9 3
PanC Rv3602c 12 4
riboflavin synthase Rv1416 56 3
riboflavin synthase Rv1412 56 3
sulfotransferase Rv1373 131 2
MshA Rv0486 80 2
MshB Rv1170 80 2
MshC Rv2130c 50 2
MshD Rv0819 50 2
IspD Rv3582c 16 5
IspE Rv1011 16 5
IspF Rv3581c 16 5
MenA Rv0534c 13 2
MenB Rv0548c 122 3
MenD Rv0555 125 2
MenE Rv0542c 122 3