Figure 4
From: Non-linear dimensionality reduction of signaling networks
Two dimensional Isomap projection of the Cytokine compendium dataset. Clusters were identified using graph-based clustering with 20-nearest neighbours distance matrix and multilevel k-way partitioning scheme for irregular graphs. High concentration Isnulin/Insulin-TNF, EGF and TNF/TNF-EGF clusters are located in the lower part of the map; the general change of the apoptosis network activity from prosurvival to prodeath is shown by the line. High concentration Insulin and insulin-TNF clusters show temporal evolution of the apoptosis network activity from early to late time points.