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Table 1 Reactions from the E. coli central metabolic network

From: Integration of enzyme activities into metabolic flux distributions by elementary mode analysis

Reaction

Gene name

Enzyme

Chemical reaction

1

ptsH, ptsI

crr, glk

Glucose phosphotransferase system

Glc + PEP => G6P + PYR

2

pfkA, pfkB

fba

tpi

Phosphofructokinase

Fructose-16-bisphosphatate aldolase

Triphosphate isomerase

F6P => 2 GAP

3

gapA

pgk

gpmA

Glycelaldehyde-3-phosphate dehydrogenase

Phosphoglycerate kinase

Phosphoglycerate mutase I

GAP => PEP

4

pykF

pykA

Pyruvate kinase I

PEP => PYR

5

aceE

aceF

lpdA

Pyruvate dehydrogenase

PYR => AcCoA

6

pta, ackA

Acetyl-CoA synthetase

AcCoA => Acetate

7

gltA

acnA, acnB

Citrate synthase

Aconitase A

AcCoA + OAA => ICT

8

icdA

Isocitrate dehydrogenase

ICT => AKG

9

sucA, sucB, lpdA

sucC, sucD

sdhC

fumA, fumB, fumC

2-ketoglutarate dehydrogenase

Succinyl-CoA synthetase

Succinate dehydrogenase

Fumarase

AKG => MAL

10

mdh

Malate dehydrogenase

MAL => OAA

11

ppc

Phosphenolpyruvate carboxylase

PEP => OAA

12

mez

Malic enzyme

MAL => PYR

13

zwf

Glucose-6-phosphate-1-dehydrogenase

G6P => 6PG

14

gnd

6-phosphoglycononate dehydrogenase

6PG => Ru5P

 

rpiA

Ribose-5-phosphate isomerase A

Ru5P => R5P

 

rpe

Ribose phosphate 3-epimerase

Ru5P => X5P

15

tktA

Transketolase I

X5P + R5P => GAP + Sed7P

16

tktB

Transketolase II

X5P + E4P => F6P +GAP

17

talB

Transaldolase B

GAP + Sed7P => F6P + E4P

18

pgi

Phosphoglucoisomerase

G6P => F6P

19

 

Glucose uptake

Glc_ext => Glc

20

 

Materials are used for biomass synthesis

G6P => Biomass

21

 

Materials are used for biomass synthesis

F6P => Biomass

22

 

Materials are used for biomass synthesis

GAP => Biomass

23

 

Materials are used for biomass synthesis

PEP =-> Biomass

24

 

Materials are used for biomass synthesis

PYR => Biomass

25

 

Materials are used for biomass synthesis

AcCoA => Biomass

26

 

Membrane transport reaction

Acetate => Acetate_ext

27

 

Materials are used for biomass synthesis

AKG => Biomass

28

 

Materials are used for biomass synthesis

OAA => Biomass

29

 

Materials are used for biomass synthesis

R5P => Biomass

30

 

Materials are used for biomass synthesis

E4P => Biomass

  1. Abbreviation: AcCoA Acetyl-CoA, AKG α-ketoglutarate, E4P erythrose-4-phosphate, F6P fructose-1,6-bisphosphate, Glc glucose, GAP glyceraldehydes-3-phosphate, G6P glucose-6-phosphate, ICT isocitrate, Mal malate, OAA oxaloacetate, PEP phosphoenolpyruvate, 6PG 6-phosphogluconate, Ru5P ribulose-5-phosphate, X5P, xylulose 5-phosphate, R5P ribose-5-phosphate, Sed7P sedoheptulose-7-phosphate, Glc_ext Glucose external, Acetate_ext Acetate external.