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Table 1 Reactions from the E. coli central metabolic network

From: Integration of enzyme activities into metabolic flux distributions by elementary mode analysis

Reaction Gene name Enzyme Chemical reaction
1 ptsH, ptsI
crr, glk
Glucose phosphotransferase system Glc + PEP => G6P + PYR
2 pfkA, pfkB
fba
tpi
Phosphofructokinase
Fructose-16-bisphosphatate aldolase
Triphosphate isomerase
F6P => 2 GAP
3 gapA
pgk
gpmA
Glycelaldehyde-3-phosphate dehydrogenase
Phosphoglycerate kinase
Phosphoglycerate mutase I
GAP => PEP
4 pykF
pykA
Pyruvate kinase I PEP => PYR
5 aceE
aceF
lpdA
Pyruvate dehydrogenase PYR => AcCoA
6 pta, ackA Acetyl-CoA synthetase AcCoA => Acetate
7 gltA
acnA, acnB
Citrate synthase
Aconitase A
AcCoA + OAA => ICT
8 icdA Isocitrate dehydrogenase ICT => AKG
9 sucA, sucB, lpdA
sucC, sucD
sdhC
fumA, fumB, fumC
2-ketoglutarate dehydrogenase
Succinyl-CoA synthetase
Succinate dehydrogenase
Fumarase
AKG => MAL
10 mdh Malate dehydrogenase MAL => OAA
11 ppc Phosphenolpyruvate carboxylase PEP => OAA
12 mez Malic enzyme MAL => PYR
13 zwf Glucose-6-phosphate-1-dehydrogenase G6P => 6PG
14 gnd 6-phosphoglycononate dehydrogenase 6PG => Ru5P
  rpiA Ribose-5-phosphate isomerase A Ru5P => R5P
  rpe Ribose phosphate 3-epimerase Ru5P => X5P
15 tktA Transketolase I X5P + R5P => GAP + Sed7P
16 tktB Transketolase II X5P + E4P => F6P +GAP
17 talB Transaldolase B GAP + Sed7P => F6P + E4P
18 pgi Phosphoglucoisomerase G6P => F6P
19   Glucose uptake Glc_ext => Glc
20   Materials are used for biomass synthesis G6P => Biomass
21   Materials are used for biomass synthesis F6P => Biomass
22   Materials are used for biomass synthesis GAP => Biomass
23   Materials are used for biomass synthesis PEP =-> Biomass
24   Materials are used for biomass synthesis PYR => Biomass
25   Materials are used for biomass synthesis AcCoA => Biomass
26   Membrane transport reaction Acetate => Acetate_ext
27   Materials are used for biomass synthesis AKG => Biomass
28   Materials are used for biomass synthesis OAA => Biomass
29   Materials are used for biomass synthesis R5P => Biomass
30   Materials are used for biomass synthesis E4P => Biomass
  1. Abbreviation: AcCoA Acetyl-CoA, AKG α-ketoglutarate, E4P erythrose-4-phosphate, F6P fructose-1,6-bisphosphate, Glc glucose, GAP glyceraldehydes-3-phosphate, G6P glucose-6-phosphate, ICT isocitrate, Mal malate, OAA oxaloacetate, PEP phosphoenolpyruvate, 6PG 6-phosphogluconate, Ru5P ribulose-5-phosphate, X5P, xylulose 5-phosphate, R5P ribose-5-phosphate, Sed7P sedoheptulose-7-phosphate, Glc_ext Glucose external, Acetate_ext Acetate external.