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Figure 4 | BMC Systems Biology

Figure 4

From: Nonlinear regulation enhances the phenotypic expression of trans- acting genetic polymorphisms

Figure 4

Dynamic model parameters and genotypic values. Correlation coefficients between genotypic values and allelic differences in values of biological parameters, in datasets of 400 simulated F2 populations for model 2 through 6 (where the highest Hill coefficient p = 5 is used). Correlations that are weaker than a threshold determined by permutations (see Methods) are set to zero. On the horizontal axis " a i - P j " and " d i - P j " denotes the genotypic values of gene i for the expression level of gene j. On the vertical axis parameter value differences between allele 1 and 2 (from parental lines P1 and P2 respectively) of gene i are denoted by Δ μ i = μ i 1 μ i 2 = α i 1 γ i 1 α i 2 γ i 2 MathType@MTEF@5@5@+=feaafiart1ev1aqatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqGHuoariiGacqWF8oqBdaWgaaWcbaGaemyAaKgabeaakiabg2da9iab=X7aTnaaBaaaleaacqWGPbqAcqaIXaqmaeqaaOGaeyOeI0Iae8hVd02aaSbaaSqaaiabdMgaPjabikdaYaqabaGccqGH9aqpdaWcaaqaaiab=f7aHnaaBaaaleaacqWGPbqAcqaIXaqmaeqaaaGcbaGae83SdC2aaSbaaSqaaiabdMgaPjabigdaXaqabaaaaOGaeyOeI0YaaSaaaeaacqWFXoqydaWgaaWcbaGaemyAaKMaeGOmaidabeaaaOqaaiab=n7aNnaaBaaaleaacqWGPbqAcqaIYaGmaeqaaaaaaaa@4E44@ and threshold value Δθ i = θi 1- θi 2(see Methods for further explanation for these parameters).

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