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Figure 2 | BMC Systems Biology

Figure 2

From: A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network

Figure 2

Negative feedback loops in the NR network. a) The protein dimerisation and protein-DNA interaction network of the NR family. Nodes represent proteins, grey edges represent protein-protein interactions and green edges represent protein-DNA interactions. Red edges represent protein-protein interactions that participate in the SHP negative feedback loops. b) The feedback loops are composed of protein dimerisation (black), protein-DNA interactions (activation: green), and inhibition through protein interaction (red).

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