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Figure 6 | BMC Systems Biology

Figure 6

From: Epstein-Barr virus latency switch in human B-cells: a physico-chemical model

Figure 6

Dynamics of EBNA-1 and Oct-2. This plot illustrates how changes in Oct-2 levels affect the EBNA-1 levels. At time zero the system is stable in latency I, with an EBNA-1 level of 850 molecules, and an Oct-2 level of 15000 molecules. Transition to latency III is induced by lowering the Oct-2 level to 10000, activating the C promoter. Reaching the stable latency III level of EBNA-1 proteins thereafter take a few days. Induced switching back to resting latency I state demands a distinct increase in Oct-2, minimum a 10 fold change (green solid line). The greater increase in Oct-2 molecules the faster the cell is switched back to a stable latency I level of EBNA-1. The green solid and dashed line illustrate two different scenarios of elevated Oct-2 levels, where the red solid and dashed line are the corresponding resulting EBNA-1 levels.

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