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Figure 4 | BMC Systems Biology

Figure 4

From: Computational cell model based on autonomous cell movement regulated by cell-cell signalling successfully recapitulates the "inside and outside" pattern of cell sorting

Figure 4

Final configurations of aggregates of randomly mixed cells with different ACTIVATION THRESHOLDs and an Hm gap preference. The following conditions were common to both cell types: DRAGGING TIME = {6, 10, or 30} SINGLE MOVING DISTANCE = 1; Hm preference. The areas of the inner cavities within the aggregates in (a), (b), (c), and (e) were 0.484, 0.428, 0.200, and 0.535, respectively; thus, all of these aggregates exhibited SSPs according to the definition described in the text. Although some aggregates occasionally exhibited an ''inside and outside'' pattern of cell-sorting, this pattern appeared only by chance and was not observed reproducibly.

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