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Figure 6 | BMC Systems Biology

Figure 6

From: Computational cell model based on autonomous cell movement regulated by cell-cell signalling successfully recapitulates the "inside and outside" pattern of cell sorting

Figure 6

Final configurations of aggregates of randomly mixed cells with different DRAGGING TIMEs. The common conditions to both cell types: ACTIVATION THRESHOLD = {0.3, 0.4, or 0.5}; SINGLE MOVING DISTANCE = 1; GAP PREFERENCE = {Htr or Hm}. The areas of the inner cavities within the aggregates in (a), (b), (g), and (h) were 0.378, 1.973, 1.675, and 0.374, respectively (SSPs). The CELL DISTRIBUTION RATIOs of the dark cell type in (c) and (d) were 3.480 ± 0.757 (S.D.) and 3.629 ± 1.314, respectively. The PERIMETER RATIOs in (c) and (d) were 0.100 ± 0.042 and 0.087 ± 0.051, respectively. Thus, (c) and (d) represented an "inside and outside" pattern. The CELL DISTRIBUTION RATIOs and PERIMETER RATIOs of the other figures are shown in Table 1.

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