Figure 1

Xenopus laevis mesendoderm migration. (Top Left) Image of Xenopus laevis mesendoderm explant, viewed from the top down. (Bottom) Schematic of mesendoderm cell shingling, where cells in the leading edge of the explant overlap the neighboring cells trailing behind them. The key parameters of the multicell model are shown, including: cadherins, integrins, and fibronectin (key located top right).