Figure 6

Schematic depicting the multiscale computational framework. The ABM outputs Fn levels at each pixel to a text file and opens a JAVA interface, which opens Matlab. Matlab imports the text file containing Fn concentrations, and the intracellular model calculates the amount of β-catenin signaling in each cell. These levels are input into the multi-cell model, and impact the extent of cadherin activation in each cell.