Initial Conditions
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Amount of Fn per patch (relative units; prescribed as the mean and standard deviation of the normal distribution)
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Mean = 250; S.D. = 50
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unpublished observation in Xenopus laevis explants
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Initial gradient of Fn (Fn concentration scaling factor for each pixel row that ensures a vertical gradient in the initial Fn concentration; higher values of this parameter generate a steeper gradient)
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10
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unpublished observation in Xenopus laevis explants
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Total number of mesendodermal cells
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53
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[9]
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Extent of cell shingling (percentage of cell surface area overlapping the neighboring cell behind it)
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77
|
[9]
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Width of explant (microns)
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85
|
[9]
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Length of explant (microns)
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309
|
[9]
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Cadherin activation (mN/m2)
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2.5
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[21]
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Integrin activation (mN/m2)
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1.5
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[21]
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Degradation of Fn
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Amount of degradation (reduction in Fn as a percentage of previous amount in that pixel prior to degradation by cell)
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0.3
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unpublished observation in Xenopus laevis explants
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Polarity Signal
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Strength (percent contribution of the polarity signal to the direction or heading of the cell)
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4.7
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hypothesized based on [25]
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Migration
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Mean distance traveled per time step (microns)
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6.5
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[9]
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