Table 1 Parameter values used in the ABM multicellular simulation.
Parameter Type | Parameter (units) | Value | Reference |
|---|---|---|---|
Initial Conditions | Amount of Fn per patch (relative units; prescribed as the mean and standard deviation of the normal distribution) | Mean = 250; S.D. = 50 | unpublished observation in Xenopus laevis explants |
| Â | Initial gradient of Fn (Fn concentration scaling factor for each pixel row that ensures a vertical gradient in the initial Fn concentration; higher values of this parameter generate a steeper gradient) | 10 | unpublished observation in Xenopus laevis explants |
| Â | Total number of mesendodermal cells | 53 | [9] |
| Â | Extent of cell shingling (percentage of cell surface area overlapping the neighboring cell behind it) | 77 | [9] |
| Â | Width of explant (microns) | 85 | [9] |
| Â | Length of explant (microns) | 309 | [9] |
| Â | Cadherin activation (mN/m2) | 2.5 | [21] |
| Â | Integrin activation (mN/m2) | 1.5 | [21] |
Degradation of Fn | Amount of degradation (reduction in Fn as a percentage of previous amount in that pixel prior to degradation by cell) | 0.3 | unpublished observation in Xenopus laevis explants |
Polarity Signal | Strength (percent contribution of the polarity signal to the direction or heading of the cell) | 4.7 | hypothesized based on [25] |
Migration | Mean distance traveled per time step (microns) | 6.5 | [9] |