|
Initial Conditions
|
Amount of Fn per patch (relative units; prescribed as the mean and standard deviation of the normal distribution)
|
Mean = 250; S.D. = 50
|
unpublished observation in Xenopus laevis explants
|
| |
Initial gradient of Fn (Fn concentration scaling factor for each pixel row that ensures a vertical gradient in the initial Fn concentration; higher values of this parameter generate a steeper gradient)
|
10
|
unpublished observation in Xenopus laevis explants
|
| |
Total number of mesendodermal cells
|
53
|
[9]
|
| |
Extent of cell shingling (percentage of cell surface area overlapping the neighboring cell behind it)
|
77
|
[9]
|
| |
Width of explant (microns)
|
85
|
[9]
|
| |
Length of explant (microns)
|
309
|
[9]
|
| |
Cadherin activation (mN/m2)
|
2.5
|
[21]
|
| |
Integrin activation (mN/m2)
|
1.5
|
[21]
|
|
Degradation of Fn
|
Amount of degradation (reduction in Fn as a percentage of previous amount in that pixel prior to degradation by cell)
|
0.3
|
unpublished observation in Xenopus laevis explants
|
|
Polarity Signal
|
Strength (percent contribution of the polarity signal to the direction or heading of the cell)
|
4.7
|
hypothesized based on [25]
|
|
Migration
|
Mean distance traveled per time step (microns)
|
6.5
|
[9]
|
