Characteristics of the EGFR frequency response. The response of the EGFR system was computed for a sinusoidal input of wavelength 200 min and a dimensionless peak value A* of 0.001. (A) The dimensionless EGFR response is plotted for various downregulation values, D. (B) In order to illustrate the time delay between the input and output waveforms, we computed the normalized response C
* by dividing the dimensionless response C* with the maximum value reached in the chosen time range. This normalized response is plotted as a function of time for the D values indicated. The input is denoted by a black dotted line. (C) The time delay between the input and output waveforms was computed using each of the maxima in the response and is plotted as a function of the peak number.