Figure 6

EGFR and GPCR systems behave like over-damped mechanical oscillators. (A) Schematic of a mass-spring-damper system. The system comprises of a mass connected to a wall via a spring with spring constant k (= mω _n ²) and a damper with damping constant B (= 2mζω _n ). The mass m is set in motion in response to the external force F, and the displacement x is a function of ω _n the natural frequency and ζ the damping ratio. (B&C) Dependence of ω _n (red line) and ζ (blue line) of the EGFR system on D (B) and of the GPCR system on k _ds (C).