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Figure 6 | BMC Systems Biology

Figure 6

From: Receptor downregulation and desensitization enhance the information processing ability of signalling receptors

Figure 6

EGFR and GPCR systems behave like over-damped mechanical oscillators. (A) Schematic of a mass-spring-damper system. The system comprises of a mass connected to a wall via a spring with spring constant k (= n 2) and a damper with damping constant B (= 2mζω n ). The mass m is set in motion in response to the external force F, and the displacement x is a function of ω n the natural frequency and ζ the damping ratio. (B&C) Dependence of ω n (red line) and ζ (blue line) of the EGFR system on D (B) and of the GPCR system on k ds (C).

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