Figure 7
Schematic flowchart of the coexpression analysis of genes based on metabolite correlations by using public transcriptome databases. The process consists of 4 steps: (1) metabolite-metabolite correlation analysis, (2) extraction of enzyme-coding genes from the AraCyc pathways, (3) coexpression analysis of the extracted enzyme-coding gene pairs, and (4) coexpression analysis of genes encoding transcription factors with the coexpressed pairs of enzyme-coding genes. Abbreviations: r Exp , weighted Pearson's correlation coefficient of a pair of enzyme-coding genes for metabolites X and Y; r CoTF , weighted Pearson's correlation coefficient of the common transcription factor (TF) gene that is coexpressed with both the enzyme-coding genes of metabolites X and Y.