Figure 6
From: Gene regulatory networks in lactation: identification of global principles using bioinformatics
Cellular localization data suggests a minority of secreted gene products during pregnancy and lactation. Differentially transcribed genes are sorted by cellular localization. Blue columns, the first of each triad, represent genes from the Pregnancy Gene Set. Red columns, the second of each triad, represent the Lactation Gene Set. Yellow columns, the third of each triad, represent the Involution Gene Set. The top half of the graph displays up-regulated genes, while the bottom half displays down-regulated genes. 'CYTOPLASMIC' refers to soluble intracellular gene products. These proteins have no transmembrane domain or signal peptide. 'SECRETED' refers to soluble secreted gene products. These proteins have a signal peptide, but no transmembrane domains. 'TYPE I,' 'TYPE II,' and 'MULTIPASS' refer to type I, type II, and multipass membrane proteins, respectively. TYPE 1 proteins have one transmembrane domain and a signal peptide, TYPE II proteins have one transmembrane domain and no signal peptide, and MULTIPASS proteins have multiple transmembrane domains. 'UNCLASSIFIED' gene products are those that do not exist in the LOCATE database.