Figure 8
From: Gene regulatory networks in lactation: identification of global principles using bioinformatics
Protein interaction networks represent differing post-transcriptional programs as a function of reproductive stage. (A-C) In each network, nodes represent proteins whose genes are up-regulated in the (A) Pregnancy, (B) Lactation, and (C) Involution Gene Sets, while (A-C) links represent interactions with other proteins in the set. (D-F) In these networks, nodes represent either a protein whose gene is up-regulated in the (D) Pregnancy, (E) Lactation, or (F) Involution Gene Set, or (D-F) another protein not in the set that directly interacts with a protein in the set. (D-F) Links represent interactions between proteins in the set with each other or with other proteins not in the set. (A-F) All network figures were produced using the Fructerman-Reingold 3D layout algorithm. Three-dimensional animations of each network with labeled nodes are provided in Additional data files 11, 12, 13, 14, 15, 16. Spreadsheets of each protein-protein interaction are provided in Additional data file 10.