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Figure 6 | BMC Systems Biology

Figure 6

From: Threshold-dominated regulation hides genetic variation in gene expression networks

Figure 6

The shaded areas are the robustness domains ΩSSP in the (μ1, μ2)-plane for (a) Models 1, 2, 11, (b) Models 3, 13, (c) Model 6, (d) Models 4, 5, 7–10, 12, 14. For parameter values in ΩSSP both x 1 ∗ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGacaGaaiaabeqaaeqabiWaaaGcbaGaemiEaG3aa0baaSqaaiabigdaXaqaaiabgEHiQaaaaaa@2F58@ and x 2 ∗ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGacaGaaiaabeqaaeqabiWaaaGcbaGaemiEaG3aa0baaSqaaiabikdaYaqaaiabgEHiQaaaaaa@2F5A@ are singular variables and approach their threshold values in the step function limit. Then they exhibit threshold robustness for all parameter perturbations which leave the perturbed values inside ΩSSP.

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