Figure 3

Common structural features of UCHL1 and of the Josephin domain of Ataxin-3. The Josephin domain of Ataxin-3 [11,12] was recently shown to initiate the aggregation of the entire protein independently of its PolyQ tract [13]. Using the DaliLite server http://www.ebi.ac.uk/DaliLite/, the superposition of UCHL1 (green, 2ETL) to the Josephin domain (orange, 1YZB) reveals a common core containing a large beta sheet surrounded by 3 superposed alpha helices.