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Figure 3 | BMC Systems Biology

Figure 3

From: A simple principle concerning the robustness of protein complex activity to changes in gene expression

Figure 3

Genes sensitive to a reduction in expression level, but not to over-expression are enriched amongst both the core and peripheral subunits of protein complexes. Percentages of genes with essential, overexpression or haploinsufficient phenotypes among different structural components of protein complexes as defined by Gavin et al. (2006). The percentages of all genes are shown for comparison. Inset: schematic representation of the overlap between the datasets used. Only 21 genes are found exclusively in modules, so we did not test these as a separate category. ** Fisher's exact test p < 0.0001 for difference between genes with the particular phenotype and all genes without that phenotype.

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