TY - JOUR AU - Durek, Pawel AU - Walther, Dirk PY - 2008 DA - 2008/11/25 TI - The integrated analysis of metabolic and protein interaction networks reveals novel molecular organizing principles JO - BMC Systems Biology SP - 100 VL - 2 IS - 1 AB - The study of biological interaction networks is a central theme of systems biology. Here, we investigate the relationships between two distinct types of interaction networks: the metabolic pathway map and the protein-protein interaction network (PIN). It has long been established that successive enzymatic steps are often catalyzed by physically interacting proteins forming permanent or transient multi-enzymes complexes. Inspecting high-throughput PIN data, it was shown recently that, indeed, enzymes involved in successive reactions are generally more likely to interact than other protein pairs. In our study, we expanded this line of research to include comparisons of the underlying respective network topologies as well as to investigate whether the spatial organization of enzyme interactions correlates with metabolic efficiency. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-2-100 DO - 10.1186/1752-0509-2-100 ID - Durek2008 ER -