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Table 4 Ten most central proteins in the fPIN.

From: The integrated analysis of metabolic and protein interaction networks reveals novel molecular organizing principles

Protein RB BN DC Protein description
ATP14 17.17 25.44 (1) 5.14 (14) ATP synthase H chain, mitochondrial
FBA1 11.34 6.71 (6) 4.45 (20) Fructose-bisphosphate aldolase
TSC13 8.49 10.28 (3) 3.07 (33) Enoyl reductase, very long fatty acid elongation
IFA38 7.73 1.26 (37) 8.59 (4) Oxidoreductase, fatty acid elongation
COX1 7.69 4.43 (14) 5.14 (15) Cytochrome c oxidase subunit 1
SER3 7.49 -0.32 (1449) 5.83 (8) D-3-phosphoglycerate dehydrogenase 1
COX5B 7.19 3.53 (17) 1.00 (117) Cytochrome c oxidase polypeptide Vb, mitochondrial [Precursor]
URA2 6.74 2.72 (21) 3.07 (31) Bifunctional glutamine-dependent carbamoyl-phosphate synthase, Aspartate carbamoyl-transferase
GPM1 6.60 2.94 (20) 2.38 (42) Phosphoglycerate mutase 1
MAE1 6.46 9.46 (4) 0.31 (160) NAD-dependent malic enzyme, mitochondrial [Precursor]
  1. Ten most central proteins in the fPIN as judged by the z-score of the change of the characteristic length of the graph after removal of a particular protein, robustness centrality (RB). For comparison to other centrality measures, the z-scores and respective rank (in parentheses) of the betweenness centrality (BN) as well as degree centrality (DC) were evaluated. The overall correlation between the centrality was RB~BN 0.70 (p-Value: 4.35E-220), RB~DC 0.59 (p-Value: 1.44E-144) and BN~DC 0.25 (p-Value 3.37E-23)