Table 1 EGFR signalling and trafficking.

1

R_A

$\frac{{\text{d[R}}_{\text{A}}]}{\text{dt}}=-{\text{ k}}_{\text{1}}{\text{[R}}_{\text{A}}{\text{][L}}_{\text{B}}\text{]}+{\text{k}}_{-\text{1}}{\text{[RL}}_{\text{A}}\text{]}-{\text{k}}_{\text{e}}{\text{[R}}_{\text{A}}\text{]}+\frac{{\text{k}}_{\text{Rsyn}}.\pi .x_{AB}.z_{AB}}{4S{A}_A}+{\Omega }_{AB}\frac{.\pi .z_{AB}\sigma .{[R0]}_A}{4SA{0}_A}$

k₁ = 3 × 10^-4

k_-1 = 0.23

k_e = 0.03

k_Rsyn = 300

[25]

[31]

2

L_B

$\frac{{\text{d[L}}_{\text{B}}]}{\text{dt}}=-{\text{k}}_{\text{1}}{\text{[R}}_{\text{A}}{\text{][L}}_{\text{B}}\text{]}+{\text{k}}_{-\text{1}}{\text{[RL}}_{\text{A}}\text{]}-{\text{k}}_{\text{clv}}{\text{[L}}_{\text{B}}\text{]}+\frac{{\text{k}}_{\text{Lsyn}}.\pi .x_{AB}.z_{AB}}{4S{A}_B}+{\Omega }_{AB}\frac{.\pi .z_{AB}\sigma .{[L0]}_B}{4SA{0}_B}$

k_Lclv = 0.005

k_Lsyn = 250

[31–33]

3

RL_A

$\frac{{\text{d[RL}}_{\text{A}}]}{\text{dt}}={\text{k}}_{\text{1}}{\text{[R}}_{\text{A}}{\text{][L}}_{\text{B}}\text{]}-{\text{k}}_{-\text{1}}{\text{[RL}}_{\text{A}}\text{]}-{\text{2k}}_{\text{2}}[R{L}_A][R{L}_A]+2k_{-2}[RL{2}_A]$

k2 = 0.001

k_2 = 6.0

[15]

4

RL2_A

$\frac{{\text{d[RL2}}_{\text{A}}]}{\text{dt}}={\text{2k}}_{\text{2}}[R{L}_A][R{L}_A]-2k_{-2}[RL{2}_A]-k_3[RL{2}_A]+k_{-3}[R{P}_A]$

k3 = 60

k_3 = 0.6

[15]

5

RP_A

$\frac{{\text{d[RP}}_{\text{A}}]}{\text{dt}}=k_3[RL{2}_A]-k_{-3}[R{P}_A]-\frac{V_4[R{P}_A]}{K_4+[R{P}_A]}-k_{\mathrm{int}}[R{P}_A]$

V4 = 2.3 × 10⁶

K4 = 3 × 10⁴

kint = 0.19

[25]