# Table 1 EGFR signalling and trafficking.

Species Rate Equation Constants Ref
1 RA k1 = 3 × 10-4
k-1 = 0.23
ke = 0.03
kRsyn = 300
[25]
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2 LB $\frac{{\text{d[L}}_{\text{B}}\right]}{\text{dt}}=-{\text{k}}_{\text{1}}{\text{[R}}_{\text{A}}{\text{][L}}_{\text{B}}\text{]}+{\text{k}}_{-\text{1}}{\text{[RL}}_{\text{A}}\text{]}-{\text{k}}_{\text{clv}}{\text{[L}}_{\text{B}}\text{]}+\frac{{\text{k}}_{\text{Lsyn}}.\pi .{x}_{AB}.{z}_{AB}}{4S{A}_{B}}+{\Omega }_{AB}\frac{.\pi .{z}_{AB}\sigma .{\left[L0\right]}_{B}}{4SA{0}_{B}}$ kLclv = 0.005
kLsyn = 250
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3 RLA $\frac{{\text{d[RL}}_{\text{A}}\right]}{\text{dt}}={\text{k}}_{\text{1}}{\text{[R}}_{\text{A}}{\text{][L}}_{\text{B}}\text{]}-{\text{k}}_{-\text{1}}{\text{[RL}}_{\text{A}}\text{]}-{\text{2k}}_{\text{2}}\left[R{L}_{A}\right]\left[R{L}_{A}\right]+2{k}_{-2}\left[RL{2}_{A}\right]$ k2 = 0.001
k_2 = 6.0
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4 RL2A $\frac{{\text{d[RL2}}_{\text{A}}\right]}{\text{dt}}={\text{2k}}_{\text{2}}\left[R{L}_{A}\right]\left[R{L}_{A}\right]-2{k}_{-2}\left[RL{2}_{A}\right]-{k}_{3}\left[RL{2}_{A}\right]+{k}_{-3}\left[R{P}_{A}\right]$ k3 = 60
k_3 = 0.6
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5 RPA $\frac{{\text{d[RP}}_{\text{A}}\right]}{\text{dt}}={k}_{3}\left[RL{2}_{A}\right]-{k}_{-3}\left[R{P}_{A}\right]-\frac{{V}_{4}\left[R{P}_{A}\right]}{{K}_{4}+\left[R{P}_{A}\right]}-{k}_{\mathrm{int}}\left[R{P}_{A}\right]$ V4 = 2.3 × 106
K4 = 3 × 104
kint = 0.19
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1. Equations relating to juxtacrine receptor – ligand interaction and receptor dimerisation and phosphorylation. Constants are either extracted directly from, inferred from or reported in the cited references. Units – All parameters relate to numbers of molecules – square brackets are for clarity only. Units are: first order rate constant: min-1; second order rate constants molecules-1 min-1, maximal enzyme rates (Vmax) are expressed in units of molecules min-1, Michaelis constants (Km) in molecules. kRsyn and kLsyn are in no. molecules cell-1 min-1. Conversions from concentrations to numbers of molecules assume a cell volume of 10-12 litres.