Multivariate gene expression analysis reveals functional connectivity changes between normal/tumoral prostates

Fujita, André; Gomes, Luciana Rodrigues; Sato, João Ricardo; Yamaguchi, Rui; Thomaz, Carlos Eduardo; Sogayar, Mari Cleide; Miyano, Satoru

doi:10.1186/1752-0509-2-106

BMC Systems Biology

Table 1 ψ_MLDA: the weights attributed by MLDA.

From: Multivariate gene expression analysis reveals functional connectivity changes between normal/tumoral prostates

	Gene name	Official Full Name	ψ _MLDA	p-value (Wilcoxon)	References:
1	*MYLK	myosin light chain kinase	0.14672	0.00000	[24]
2	*KLK2	kallikrein-related peptidase 2	0.12512	0.01053	[49]
3	*KLK3	kallikrein-related peptidase 3	0.12032	0.05625	[50]
4	HAN11	WD repeat domain 68	0.12019	0.00000
5	*LTF	lactotransferrin	0.11594	0.00092	[39]
6	CSRP1	cysteine and glycine-rich protein 1	0.11355	0.00000	[51]
7	*TGM4	transglutaminase 4 (prostate)	0.10452	0.06063	[42]
8	*ACTG2	actin gamma 2 smooth muscle enteric	0.09826	0.00000	[52]
9	MYL6	myosin light chain 6 alkali smooth muscle and non-muscle	0.09817	0.00045	[53]
10	*RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.09583	0.00018	[54]
11	*AZGP1	alpha-2-glycoprotein 1 zinc-binding	0.08817	0.00059	[55]
12	NPAL3	NIPA-like domain containing 3	0.08478	0.00008
13	PRO1073	PRO1073 protein	0.08077	0.28733
14	*FXYD3	FXYD domain containing ion transport regulator 3	0.08024	0.05417	[56]
15	TPM2	tropomyosin 2 (beta)	0.07919	0.00001	[57]
16	CRYAB	crystallin alpha B	0.07560	0.00000	[58]
17	ACTA2	actin alpha 2 smooth muscle aorta	0.07372	0.01610	[59]
18	*RPS6	ribosomal protein S6	0.07323	0.12130	[60]
19	TMEM130	transmembrane protein 130	0.07296	0.00005
20	*ACPP	acid phosphatase prostate	0.07185	0.00037	[61]
21	*PCP4	Purkinje cell protein 4	0.07128	0.00000	[62]
22	*SYNPO2	synaptopodin 2	0.06943	0.00000	[63]
23	*SORBS1	sorbin and SH3 domain containing 1	0.06773	0.00000	[64]
24	*MSMB	microseminoprotein beta	0.06588	0.00076	[65]
25	ACTC	actin alpha cardiac muscle 1	0.06335	0.00001
26	*TGFB3	transforming growth factor beta 3	0.06313	0.00000	[66]
27	*MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.06205	0.14208	[67]
28	ZNF532	zinc finger protein 532	0.06131	0.00000
29	ANXA1	annexin A1	0.06119	0.00001	[68]
30	PALLD	palladin cytoskeletal associated protein	0.06116	0.00000	[69]
31	*MT2A	metallothionein 2A	0.06054	0.00141	[70]
32	ING5	inhibitor of growth family member 5	0.05872	0.93009	[71]
33	PGM5	phosphoglucomutase 5	0.05862	0.00000
34	SERPINA3	serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 3	0.05828	0.19710	[72]
35	*KRT5	keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types)	0.05699	0.00000	[73]
36	RPL5	ribosomal protein L5	0.05589	0.53873	[74]
37	*IGF1	insulin-like growth factor 1 (somatomedin C)	0.05549	0.00000	[75]
38	ZNF92	zinc finger protein 92 (HTF12)	0.05388	0.16056
39	*FOLH1	folate hydrolase (prostate-specific membrane antigen) 1	0.05361	0.08683	[76]
40	*CYR61	cysteine-rich angiogenic inducer 61	0.05318	0.00020	[77]
41	FHL1	four and a half LIM domains 1	0.05305	0.00000	[78]
42	*H19	H19 imprinted maternally expressed transcript	0.05221	0.00006	[79]
43	DMN	desmuslin	0.05219	0.00000
44	NEFH	neurofilament heavy polypeptide 200 kDa	0.05186	0.00001	[80]
45	PPP1R12B	protein phosphatase 1 regulatory (inhibitor) subunit 12B	0.05149	0.00000
46	ANTXR2	anthrax toxin receptor 2	0.05141	0.00002	[81]
47	MRLC2	myosin regulatory light chain MRLC2	0.05056	0.02204	[82]
48	C20orf103	chromosome 20 open reading frame 103	0.05055	0.00150
49	UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1	0.05033	0.00518	[83]
50	TRGV9	T cell receptor gamma variable 9	0.04983	0.00190
51	*SPARC	secreted protein acidic cysteine-rich (osteonectin)	0.04969	0.00240	[84]
52	*AMACR	alpha-methylacyl-CoA racemase	0.04903	0.00011	[85]
53	DNER	delta/notch-like EGF repeat containing	0.04809	0.09301	[86]
54	PRNP	prion protein (p27-30)	0.04806	0.00000	[87]
55	PDK4	pyruvate dehydrogenase kinase isozyme 4	0.04751	0.00002	[88]
56	*APOD	apolipoprotein D	0.04744	0.12931	[89]
57	*HERPUD1	homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1	0.04695	0.00001	[90]
58	FSTL1	follistatin-like 1	0.04692	0.00092	[91]
59	HSPCB	heat shock protein 90 kDa alpha (cytosolic) class B member 1	0.04663	0.08386	[92]
60	*GSTM2	glutathione S-transferase M2 (muscle)	0.04446	0.00000	[93]
61	*PTN	pleiotrophin	0.04440	0.00000	[94]
62	*ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.04410	0.06528	[95]
63	*CTGF	connective tissue growth factor	0.04342	0.00004	[96]
64	*GUCY1A3	guanylate cyclase 1 soluble alpha 3	0.04303	0.05841	[97]
65	MT1F	metallothionein 1F	0.04303	0.00002	[98]
66	*TIMP3	TIMP metallopeptidase inhibitor 3	0.04225	0.00000	[99]
67	*LDHB	lactate dehydrogenase B	0.04217	0.00000	[100]
68	RNASE4	ribonuclease RNase A family 4	0.04167	0.00000
69	ANPEP	alanyl aminopeptidase	0.04165	0.00002	[101]
70	*CAV1	caveolin 1 caveolae protein 22 kDa	0.04135	0.00000	[102]
71	TM9SF2	transmembrane 9 superfamily member 2	0.04122	0.01275
72	*HSPB8	heat shock 22 kDa protein 8	0.04088	0.00000	[103]
73	TUBA1A	tubulin alpha 1a	0.04087	0.00018
74	PDLIM5	PDZ and LIM domain 5	0.04077	0.32533	[104]
75	LPP	LIM domain containing preferred translocation partner in lipoma	0.04073	0.00003	[105]
76	MAD2L1BP	MAD2L1 binding protein	0.04051	0.62639	[106]
77	*ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif 1	0.04048	0.00011	[107]
78	*RHOA	ras homolog gene family member A	0.04039	0.11368	[108]
79	*TXNIP	thioredoxin interacting protein	0.03995	0.00227	[109]
80	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.03974	0.07543
81	RPL35	ribosomal protein L35	0.03971	0.17555
82	*ANKH	ankylosis progressive homolog (mouse)	0.03856	0.00318	[110]
83	MPST	mercaptopyruvate sulfurtransferase	0.03856	0.00000	[111]
84	MORF4L2	mortality factor 4 like 2	0.03831	0.01337	[112]
85	CRISPLD2	cysteine-rich secretory protein LCCL domain containing 2	0.03799	0.00000
86	*CD9	CD9 molecule	0.03787	0.00150	[113]
87	ALDH3A2	aldehyde dehydrogenase 3 family member A2	0.03696	0.00001
88	SCN2B	sodium channel voltage-gated type II beta	0.03693	0.00024	[114]
89	*SPARCL1	SPARC-like 1 (mast9 hevin)	0.03693	0.00045	[115]
90	IGJ	immunoglobulin J polypeptide linker protein for immunoglobulin alpha and mu polypeptides	0.03683	0.00190	[116]
91	ZNF134	zinc finger protein 134	0.03670	0.00007
92	MRPL43	mitochondrial ribosomal protein L43	0.03655	0.54934
93	LOC152485	hypothetical protein LOC152485	0.03647	0.00000
94	CALM2	calmodulin 2 (phosphorylase kinase delta)	0.03622	0.05417	[117]
95	COL9A2	collagen type IX alpha 2	0.03546	0.00141
96	*PAGE4	P antigen family member 4 (prostate associated)	0.03541	0.00001	[118]
97	CALM1	calmodulin 1 (phosphorylase kinase delta)	0.03536	0.00098	[119]
98	*ACTB	actin beta	0.03508	0.01159	[120]
99	*AGR2	anterior gradient homolog 2 (Xenopus laevis)	0.03498	0.56006	[121]
100	RPS28	ribosomal protein S28	0.03497	0.15578

*: genes already described to be related to prostatic cancer. In bold are the genes which do not present statistical evidences to be differentially expressed between normal and tumoral conditions.

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ISSN: 1752-0509

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