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Table 1 ψMLDA: the weights attributed by MLDA.

From: Multivariate gene expression analysis reveals functional connectivity changes between normal/tumoral prostates

  Gene name Official Full Name ψ MLDA p-value (Wilcoxon) References:
1 *MYLK myosin light chain kinase 0.14672 0.00000 [24]
2 *KLK2 kallikrein-related peptidase 2 0.12512 0.01053 [49]
3 *KLK3 kallikrein-related peptidase 3 0.12032 0.05625 [50]
4 HAN11 WD repeat domain 68 0.12019 0.00000  
5 *LTF lactotransferrin 0.11594 0.00092 [39]
6 CSRP1 cysteine and glycine-rich protein 1 0.11355 0.00000 [51]
7 *TGM4 transglutaminase 4 (prostate) 0.10452 0.06063 [42]
8 *ACTG2 actin gamma 2 smooth muscle enteric 0.09826 0.00000 [52]
9 MYL6 myosin light chain 6 alkali smooth muscle and non-muscle 0.09817 0.00045 [53]
10 *RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.09583 0.00018 [54]
11 *AZGP1 alpha-2-glycoprotein 1 zinc-binding 0.08817 0.00059 [55]
12 NPAL3 NIPA-like domain containing 3 0.08478 0.00008  
13 PRO1073 PRO1073 protein 0.08077 0.28733  
14 *FXYD3 FXYD domain containing ion transport regulator 3 0.08024 0.05417 [56]
15 TPM2 tropomyosin 2 (beta) 0.07919 0.00001 [57]
16 CRYAB crystallin alpha B 0.07560 0.00000 [58]
17 ACTA2 actin alpha 2 smooth muscle aorta 0.07372 0.01610 [59]
18 *RPS6 ribosomal protein S6 0.07323 0.12130 [60]
19 TMEM130 transmembrane protein 130 0.07296 0.00005  
20 *ACPP acid phosphatase prostate 0.07185 0.00037 [61]
21 *PCP4 Purkinje cell protein 4 0.07128 0.00000 [62]
22 *SYNPO2 synaptopodin 2 0.06943 0.00000 [63]
23 *SORBS1 sorbin and SH3 domain containing 1 0.06773 0.00000 [64]
24 *MSMB microseminoprotein beta 0.06588 0.00076 [65]
25 ACTC actin alpha cardiac muscle 1 0.06335 0.00001  
26 *TGFB3 transforming growth factor beta 3 0.06313 0.00000 [66]
27 *MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.06205 0.14208 [67]
28 ZNF532 zinc finger protein 532 0.06131 0.00000  
29 ANXA1 annexin A1 0.06119 0.00001 [68]
30 PALLD palladin cytoskeletal associated protein 0.06116 0.00000 [69]
31 *MT2A metallothionein 2A 0.06054 0.00141 [70]
32 ING5 inhibitor of growth family member 5 0.05872 0.93009 [71]
33 PGM5 phosphoglucomutase 5 0.05862 0.00000  
34 SERPINA3 serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 3 0.05828 0.19710 [72]
35 *KRT5 keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types) 0.05699 0.00000 [73]
36 RPL5 ribosomal protein L5 0.05589 0.53873 [74]
37 *IGF1 insulin-like growth factor 1 (somatomedin C) 0.05549 0.00000 [75]
38 ZNF92 zinc finger protein 92 (HTF12) 0.05388 0.16056  
39 *FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.05361 0.08683 [76]
40 *CYR61 cysteine-rich angiogenic inducer 61 0.05318 0.00020 [77]
41 FHL1 four and a half LIM domains 1 0.05305 0.00000 [78]
42 *H19 H19 imprinted maternally expressed transcript 0.05221 0.00006 [79]
43 DMN desmuslin 0.05219 0.00000  
44 NEFH neurofilament heavy polypeptide 200 kDa 0.05186 0.00001 [80]
45 PPP1R12B protein phosphatase 1 regulatory (inhibitor) subunit 12B 0.05149 0.00000  
46 ANTXR2 anthrax toxin receptor 2 0.05141 0.00002 [81]
47 MRLC2 myosin regulatory light chain MRLC2 0.05056 0.02204 [82]
48 C20orf103 chromosome 20 open reading frame 103 0.05055 0.00150  
49 UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.05033 0.00518 [83]
50 TRGV9 T cell receptor gamma variable 9 0.04983 0.00190  
51 *SPARC secreted protein acidic cysteine-rich (osteonectin) 0.04969 0.00240 [84]
52 *AMACR alpha-methylacyl-CoA racemase 0.04903 0.00011 [85]
53 DNER delta/notch-like EGF repeat containing 0.04809 0.09301 [86]
54 PRNP prion protein (p27-30) 0.04806 0.00000 [87]
55 PDK4 pyruvate dehydrogenase kinase isozyme 4 0.04751 0.00002 [88]
56 *APOD apolipoprotein D 0.04744 0.12931 [89]
57 *HERPUD1 homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 0.04695 0.00001 [90]
58 FSTL1 follistatin-like 1 0.04692 0.00092 [91]
59 HSPCB heat shock protein 90 kDa alpha (cytosolic) class B member 1 0.04663 0.08386 [92]
60 *GSTM2 glutathione S-transferase M2 (muscle) 0.04446 0.00000 [93]
61 *PTN pleiotrophin 0.04440 0.00000 [94]
62 *ERG v-ets erythroblastosis virus E26 oncogene homolog (avian) 0.04410 0.06528 [95]
63 *CTGF connective tissue growth factor 0.04342 0.00004 [96]
64 *GUCY1A3 guanylate cyclase 1 soluble alpha 3 0.04303 0.05841 [97]
65 MT1F metallothionein 1F 0.04303 0.00002 [98]
66 *TIMP3 TIMP metallopeptidase inhibitor 3 0.04225 0.00000 [99]
67 *LDHB lactate dehydrogenase B 0.04217 0.00000 [100]
68 RNASE4 ribonuclease RNase A family 4 0.04167 0.00000  
69 ANPEP alanyl aminopeptidase 0.04165 0.00002 [101]
70 *CAV1 caveolin 1 caveolae protein 22 kDa 0.04135 0.00000 [102]
71 TM9SF2 transmembrane 9 superfamily member 2 0.04122 0.01275  
72 *HSPB8 heat shock 22 kDa protein 8 0.04088 0.00000 [103]
73 TUBA1A tubulin alpha 1a 0.04087 0.00018  
74 PDLIM5 PDZ and LIM domain 5 0.04077 0.32533 [104]
75 LPP LIM domain containing preferred translocation partner in lipoma 0.04073 0.00003 [105]
76 MAD2L1BP MAD2L1 binding protein 0.04051 0.62639 [106]
77 *ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 0.04048 0.00011 [107]
78 *RHOA ras homolog gene family member A 0.04039 0.11368 [108]
79 *TXNIP thioredoxin interacting protein 0.03995 0.00227 [109]
80 OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.03974 0.07543  
81 RPL35 ribosomal protein L35 0.03971 0.17555  
82 *ANKH ankylosis progressive homolog (mouse) 0.03856 0.00318 [110]
83 MPST mercaptopyruvate sulfurtransferase 0.03856 0.00000 [111]
84 MORF4L2 mortality factor 4 like 2 0.03831 0.01337 [112]
85 CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 0.03799 0.00000  
86 *CD9 CD9 molecule 0.03787 0.00150 [113]
87 ALDH3A2 aldehyde dehydrogenase 3 family member A2 0.03696 0.00001  
88 SCN2B sodium channel voltage-gated type II beta 0.03693 0.00024 [114]
89 *SPARCL1 SPARC-like 1 (mast9 hevin) 0.03693 0.00045 [115]
90 IGJ immunoglobulin J polypeptide linker protein for immunoglobulin alpha and mu polypeptides 0.03683 0.00190 [116]
91 ZNF134 zinc finger protein 134 0.03670 0.00007  
92 MRPL43 mitochondrial ribosomal protein L43 0.03655 0.54934  
93 LOC152485 hypothetical protein LOC152485 0.03647 0.00000  
94 CALM2 calmodulin 2 (phosphorylase kinase delta) 0.03622 0.05417 [117]
95 COL9A2 collagen type IX alpha 2 0.03546 0.00141  
96 *PAGE4 P antigen family member 4 (prostate associated) 0.03541 0.00001 [118]
97 CALM1 calmodulin 1 (phosphorylase kinase delta) 0.03536 0.00098 [119]
98 *ACTB actin beta 0.03508 0.01159 [120]
99 *AGR2 anterior gradient homolog 2 (Xenopus laevis) 0.03498 0.56006 [121]
100 RPS28 ribosomal protein S28 0.03497 0.15578  
  1. *: genes already described to be related to prostatic cancer. In bold are the genes which do not present statistical evidences to be differentially expressed between normal and tumoral conditions.