Modelling phagosomal lipid networks that regulate actin assembly

BMC Systems Biology

Table 3 Parameter estimation for actin nucleation (sub-model III)

Parameter	units	Value	sensitivity (ΔlnSS/Δlnp)
pPI	l/μmol	0.00	-
pPIP	l/μmol	0.724	2.18
pPIP2	l/μmol	0.819	0.96
pPA*ATP	l²/μmol²	3.05E-05	1.08
qATP	l/μmol	0.00085	0.61
qDAG	l/μmol	0.312	3.28
qPC	l/μmol	1.83	0.36

The results of actin nucleation (mean of 3 to 5 independent experiments) in the presence of 0.2 or 5 mM ATP with the addition of different lipids and the COPASI program were used to estimate parameters. Sensitivity for each parameter was calculated as explained in Methods.

ISSN: 1752-0509