(A) Systems Analysis
| | | | | | |
(i) Network
|
3405
| |
431
|
2974
| |
Single node deletions
|
(ii) FBA
| | | | | | |
a) Mtb iNJ 661
|
661
| |
229
|
432
| |
FBA
|
b) GSMN-TB
|
717
| |
259
|
458
| |
FBA
|
c) MAP
|
26
| |
15
|
11
| |
FBA
|
(iii) TraSH
|
3186
| |
656
|
2530
| | |
Summary ((i) or (ii) or (iii))
|
3823
|
166 (A')
|
1138
|
2685
|
(AX)
| |
(B) Sequence Analysis
|
3989
| |
3611
|
378
|
(BX)
|
3,989 Mtb vs. 33,453 human sequence comparisons
|
(A&B) Systems & Sequence Passed
|
3989
|
-
|
942
|
3047
|
(AX∪ BX)
| |
(C) Structural Assessment (PMScore < 0:8) [942 from A&B only considered]
|
767
|
175 (C')
|
622
|
145
|
(CX)
|
3,500 sites of Mtb (767 proteins) vs 70,149 sites of Human pocketome (15,830 proteins) = 245,521,500 pairwise comparisons
|
(D) A & B & C
|
3989
|
-
|
622
|
3552
|
(AX∪ BX∪ CX∪ C') | |
(E) Expression
| | | | | | |
(i) Gao-expression
|
3590
|
399
|
2210
|
1380
| | |
(ii) Rachman-expression
|
634
|
3355
|
634
|
-
| | |
(iii) Boshoff-expression
|
3915
|
74
|
3915
|
-
| | |
Summary ((i) or (ii) or (iii))
|
3917
|
72
|
3264
|
653
|
(EX)
| |
Summary (for (D))
|
622
|
1
|
529
|
92
| | |
(F) Non-similarity to Anti-targets
|
3989
|
-
|
3928
|
61
|
(FX)
|
306 vs. 3,989 sequence comparisons
|
Non-similarity to Anti-targets (for (D))
|
622
|
-
|
611
|
11
| | |
(G) Non-similarity to gut flora
|
3989
|
-
|
3730
|
259
|
(GX)
|
296,017 vs. 3,989 sequence comparisons
|
Non-similarity to gut flora (for (D))
|
622
|
-
|
543
|
79
| | |
(H) D & E & F &; G
|
622
|
1
|
451
|
170
| | |
(I) Expression during Persistence
| | | | | | |
(i) Muttucumaru-expression
|
3924
|
82
|
639
|
3268
| | |
(ii) Boshoff-expression
|
3915
|
74
|
105
|
3810
| | |
(iii) Betts-expression
|
3649
|
340
|
274
|
3375
| | |
(iv) Voskuil-expression
|
3924
|
82
|
310
|
3597
| | |
(v) Hampshire-expression
|
3757
|
395
|
1349
|
2245
| | |
Summary ((i) or (ii) or (iii) or (iv) or (v))
|
3933
|
73
|
1871
|
2045
| | |
Summary (for (H))
|
451
|
-
|
216
|
235
| | |
(J) Broad-spectrum Targets [present in > 100/228 pathogenic genomes]
|
451
|
-
|
186
|
265
| |
2,295,901 vs. 3,989 sequence comparisons (phylo-Genetic profiling against 707 genomes)
|
(K) Targets unique to Mycobacteria
|
451
|
-
|
66
|
385
| | |