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Figure 10 | BMC Systems Biology

Figure 10

From: Essential operating principles for tumor spheroid growth

Figure 10

SMS cross-sections at varied proNut and low NUTRIENT. All images were recorded at 18 DAYS. Scale bar: 100 μm. Other parameter values were those listed in Table 2. (A)-(H)proNut values are shown. *:proNut value in Table 2. Note that while size increased initially with increasing proNut (a consequence of increased numbers of lower-consumption rate quiescent CELLS), larger proNut values caused the proliferating rim to become so thin that the SMS destabilized. The more quickly CELLS that are incapable of proliferating transition to the (lower-consumption) QUIESCENT state, the larger the size of the stable SMS.

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