Figure 3

EMT6 and SMS growth curves. In vitro growth values (gray diamonds) were adapted from [13] by calculating spheroid diameters from measured volumes, assuming a circular cross-section. SMS values were obtained by specifying that CELL diameter maps to 10 μm, measuring the greatest X, Y extents, excluding isolated CELLS, and assuming a circular cross-section. Parameter values were those listed in Table 2. (A) SMS growth at high NUTRIENT. Values are means of ten runs. EMT6 spheroid values were from [13] at 0.28 mM oxygen and 16.5 mM glucose. (B) SMS growth was under low NUTRIENT. Values are means of ten runs. EMT6 spheroid values from [13] at 0.07 mM oxygen and 0.8 mM glucose.