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Table 4 Comparison of in vitro and in silico growth characteristics.

From: Essential operating principles for tumor spheroid growth

Condition

Initial doubling time

Viable rim width

Necrosis onset time

Necrosis onset size

Maximum area

In silico

     

   High NUTRIENT*

21.4 HOURS/19.2 HOURS‡

245 μm

11.4 DAYS

0.253 mm2

1.61 mm2 ‡/1.46 mm2‡

   Low NUTRIENT*

40.0 HOURS/19.2 HOURS‡

62 μm

4.4 DAYS

0.0266 mm2

0.0645 mm2‡

In vitro

     

   16.5 mM glucose & 0.28 mM oxygen

23.0 hours†/21.6 hours‡

240 μm

N/A

0.209 mm2

3.25 mm2 †/2.79 mm2‡

   0.8 mM glucose & 0.07 mM oxygen

17.0 hours†/26.4 hours‡

60 μm

N/A

0.0181 mm2

0.221 mm2 †/0.0725 mm2‡

  1. * Values for mean of ten runs.
  2. † From Gompertz fit by Freyer and Sutherland [13].
  3. ‡ From Gompertz fit by authors.