From: Essential operating principles for tumor spheroid growth
Condition | Initial doubling time | Viable rim width | Necrosis onset time | Necrosis onset size | Maximum area |
---|---|---|---|---|---|
In silico | Â | Â | Â | Â | Â |
   High NUTRIENT* | 21.4 HOURS/19.2 HOURS‡ | 245 μm | 11.4 DAYS | 0.253 mm2 | 1.61 mm2 ‡/1.46 mm2‡ |
   Low NUTRIENT* | 40.0 HOURS/19.2 HOURS‡ | 62 μm | 4.4 DAYS | 0.0266 mm2 | 0.0645 mm2‡ |
In vitro | Â | Â | Â | Â | Â |
   16.5 mM glucose & 0.28 mM oxygen | 23.0 hours†/21.6 hours‡ | 240 μm | N/A | 0.209 mm2 | 3.25 mm2 †/2.79 mm2‡ |
   0.8 mM glucose & 0.07 mM oxygen | 17.0 hours†/26.4 hours‡ | 60 μm | N/A | 0.0181 mm2 | 0.221 mm2 †/0.0725 mm2‡ |