Three pathways with the highest scores in Query 1. For conciseness, a common reaction in S. cerevisiae and E. coli is drawn only once in each building block. The solid-headed arrow indicates the reactions exist in both species, constituting an "i-i-i-i" pathway. a. Z(P) = 41. Involved KEGG maps include: glycolysis/gluconeogenesis; pentose phosphate pathway; starch and sucrose metabolism; phenylalanine, tyrosine and tryptophan biosynthesis. b. Z(P) = 40. Involved KEGG maps include: pentose phosphate pathway; glycolysis/gluconeogenesis; starch and sucrose metabolism; glutathione metabolism. c. Z(P) = 39. Involved KEGG maps include: starch and sucrose metabolism; glycolysis/gluconeogenesis; galactose metabolism; streptomycin biosynthesis; pentose phosphate pathway.