Two examples of non-"i-i-i-i" best pathways in Query 1. The non-identical building blocks are highlighted, which exhibit diversities. Scores of all building blocks are shown at the bottom right. The involved KEGG maps are: a. galactose metabolism; fructose and mannose metabolism; glycolysis/gluconeogenesis; pentose phosphate pathway. b. citrate cycle (TCA cycle); glyoxylate and dicarboxylate metabolism; urea cycle and metabolism of amino groups; alanine and aspartate metabolism; arginine and proline metabolism; butanoate metabolism (only for E. coli); reductive carboxylate cycle (CO2 fixation) (only for E. coli).