Clustering-coefficient profiles for the RG-projected networks under directed attacks to the best connected transcription factors and regulated genes. We show the clustering coefficient value according to the color bar. a) E. coli original network. b) S. cerevisiae original network. c) E. coli randomized network. d) S. cerevisiae randomized network. We observe that no appreciable differences are present between original and random networks. Remarkably, both organisms organisms are more robust against RG attacks than they are to TF attacks.