Figure 5

Comparative ranking analysis. Each column corresponds to the three human GO networks analyzed here: the complete GO network (ALL), the GO network of up-regulated nodes only (UP) and the GO network of down-regulated nodes only (DOWN). The GO terms are colored based on scores (green: p-value < 0.01; yellow: 0.01 <p-value < 0.05; red: p-value > 0.05), and all Reporter GO terms with a p-value < 0.01 in at least one of the networks are displayed. Genes belonging to the GO terms DNA-directed RNA polymerase activity, ceramide metabolism and NADH dehydrogenase (ubiquinone) activity are mostly up-regulated in the diabetic patients, while genes belonging to the GO terms generation of precursor metabolites, mitochondrial inner membrane, TCA cycle and glycolysis are mostly down-regulated in diabetic cases.