Distribution of control. The organizational logic of transcriptional regulation revealed by combining the information on digital control (obtained from intra-strain experiments), and information on analog control (obtained from inter-strain experiments). Red arrows indicate the links of the effective TRNs. Colored segments on the circular genome are affected genes, as derived from the fis (blue) and hns (yellow) inter-strain experiments. The colored spheres indicate connected components in the effective GPN at a proximity threshold of t = 5 kb. The actual size of the spheres is proportional to the diameter of the subnets spanned by each analyzed profile. The origin (Ori) and terminus (Ter) of chromosomal replication are also shown.