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Table 2 Top ten functions/diseases and their respective top ten signaling pathways in high fertility group spermatozoa.

From: Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility

  Signaling Pathways
Functions & diseases EGF signaling PDGF signaling Integrin signaling Amyloid processing Complement and Coagulation cascade PPAR signaling Neurotrophin signaling Huntingtons disease signaling IGF1 Signaling Apoptosis signaling
Cell cycle 12 14 13 10 4 11 11 13 14 10
Cellular movement 9 12 25 10 11 13 9 12 11 14
Connective tissue development and function 3 4 7 5 2 2 3 2 5 2
Cellular assembly and Organization 3 5 15 9 3 4 4 5 4 7
Cell morphology 15 17 31 10 6 10 15 16 14 12
Cardio-vascular disease 4 5 3 5 3 2 3 7 3 7
Lipid metabolism 2 2 2 2 1 2 2 3 2 2
Small molecule Biochemistry 9 10 12 12 1 6 8 9 12 12
Cell to cell signaling and interaction 6 8 22 3 13 3 5 6 7 7
Post translational modification 8 10 14 13 1 7 7 9 9 10
  1. EGF: Epidermal Growth Factor; PDGF: Platelet Derived Growth Factor; IGF1: Insulin Growth Factor-1.