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Table 2 Top ten functions/diseases and their respective top ten signaling pathways in high fertility group spermatozoa.

From: Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility

 

Signaling Pathways

Functions & diseases

EGF signaling

PDGF signaling

Integrin signaling

Amyloid processing

Complement and Coagulation cascade

PPAR signaling

Neurotrophin signaling

Huntingtons disease signaling

IGF1 Signaling

Apoptosis signaling

Cell cycle

12

14

13

10

4

11

11

13

14

10

Cellular movement

9

12

25

10

11

13

9

12

11

14

Connective tissue development and function

3

4

7

5

2

2

3

2

5

2

Cellular assembly and Organization

3

5

15

9

3

4

4

5

4

7

Cell morphology

15

17

31

10

6

10

15

16

14

12

Cardio-vascular disease

4

5

3

5

3

2

3

7

3

7

Lipid metabolism

2

2

2

2

1

2

2

3

2

2

Small molecule Biochemistry

9

10

12

12

1

6

8

9

12

12

Cell to cell signaling and interaction

6

8

22

3

13

3

5

6

7

7

Post translational modification

8

10

14

13

1

7

7

9

9

10

  1. EGF: Epidermal Growth Factor; PDGF: Platelet Derived Growth Factor; IGF1: Insulin Growth Factor-1.