Data integration scheme: Protein-protein interaction networks unravel the link between gene expression and SEREX-ovarian data, via identified transcription factors. One of the newly identified autoantigens, DDX21, is included. The protein network was generated using genes identified by Meta-UP and SEREX-ovarian dataset searches. Genes shown in the upper right present a sample of the network, linking the various data sources to the newly identified autoantigen DDX21. In the lower left of the Figure, ELISA signal intensities of the 20 individual ovarian cancer sera tested on DDX21 are given as bar plots. Genes involved can be further grouped using gene ontology terms, showing typical gene categories involved in cancer.