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Table 1 List of 86 upregulated genes (Meta-UP) derived from literature meta-analysis. Only genes reported at least twice in the 20 publications reviewed were considered. The total numbers of reported upregulated (U) and downregulated (D) genes are provided. Rows in bold indicate protein products that are autoantigens, either reported in the literature or in the SEREX-ovarian dataset.

From: Linking the ovarian cancer transcriptome and immunome

Symbol

Gene Name (short)

U

D

Symbol

Gene Name (short)

U

D

MUC1

mucin 1, transmembrane

7

1

H2AFZ

H2A histone family, member Z

2

0

FOLR1

folate receptor 1

5

0

HIST1H2AC

histone 1, H2ac

2

0

KLK7

kallikrein 7

5

0

HIST1H2BD

histone 1, H2bd

2

0

TACSTD1

tumor assoc. calcium signal transducer 1

6

1

HMGB1

high mobility group box 1

2

0

CD47

CD47 antigen

5

1

HP

hyptoglobin

2

0

CLDN4

claudin 4

5

1

HSPCA

heat shock 90 kDa protein 1, alpha-like 3

2

0

CP

ceruloplasmin

4

0

IGLL1

immunoglobulin lambda-like polypeptide 1

2

0

CRABP1

cellular retinoic acid binding protein 1

4

0

ITGB8

integrin beta 8

2

0

KLK6

kallikrein 6

5

1

JAG2

jagged 2

2

0

PRAME

preferentially expressed antigen in melanoma

4

0

KLK5

kallikrein 5

2

0

WFDC2

WAP four disulfide core domain 2

4

0

KLK8

kallikrein 8

2

0

APOE

apolipoprotein E

3

0

KRT8

keratin 8

2

0

CD24

CD24 antigen

4

1

LCN2

lipocalcin 2

3

1

CD9

CD9 antigen

3

0

LOC389831

hypothetical gene supported by AL713796

2

0

CKS1B

CDC28 protein kinase regulatory subunit 1B

3

0

LU

lutheran blood group

2

0

HLA-DPB1

MHC class II, DP beta 1

3

0

MAL

Mal, T-cell differentiation protein

3

1

KRT18

keratin 18

3

0

MAL2

Mal, T-cell differentiation protein 2

2

0

PRKCI

protein kinase C

3

0

MEIS1

Meis 1, myeloid ecotropic viral integration site

2

0

SLPI

secretory leukocyte protease inhibitor

4

1

MP14

matrix metalloprotease 14

2

0

SPINT2

serine protease inhibitor

3

0

MSLN

mesothelin

2

0

ADAMTS5

disintegrin-like, metalloprotease

2

0

MYCl1

V-myc myelocytomastosis viral oncogene

2

0

ANK3

ankyrin 3

2

0

PAX8

paired box gene 8

3

1

ATF3

activating transcription factor 3

2

0

PEA15

phosphoprotein enriched in astrocytes 15

2

0

BARD1

BRCA1 associated RING domain 1

2

0

PRKCBP1

protein kinase C binding protein 1

2

0

BCL2L1

Bcl-2 like 1

2

0

PRKCH

protein kinase C

2

0

BMP7

bone morphogenetic protein 1

3

1

S100A1

S100 calcium binding protein A1

3

1

CD44

CD44 antigen

2

0

SCGB2A1

secretoglobin family 2A member 1

2

0

CKB

creatine kinase, brain

2

0

SCNN1A

sodium channel, non-voltage gated

2

0

CLU

clusterin

2

0

SDC4

syndecan 4

2

0

COL5A1

collagen type V alpha 1

2

0

SIAHBP1

fuse binding protein interacting repressor

2

0

COL9A2

collagen type IX alpha 2

2

0

SLC7A5

solute carrier family 7, member 5

2

0

CRABP2

cellular retinoic acid binding protein 2

2

0

SOX9

SRY-box 9

2

0

D2S448

melanoma associated gene

2

0

SPON1

spondin 1, extracellular matrix protein

2

0

DPM1

dolichyl-phosphate mannosyltransferase polypeptide 1

2

0

VEGF

vascular endothelial growth factor

2

0

EDD

E3 identified by differential display

2

0

CLDN3

claudin 3

2

1

EFNA1

ephirin A1

3

1

IGKC

immunoglobulin kappa constant

2

1

ELF3

E74 like factor 3

2

0

KLK10

kallikrein 10

2

1

EYA2

eyes absent homolog 2 (Drosophila)

2

0

KRT19

keratin 19

2

1

FLJ20171

hypothetical protein FLJ20171

2

0

NMU

neuromedin U

2

1

FLT1

fms-related tyrosine kinase 1

2

0

PTPRF

protein tyrosine phosphatase, receptor type, F

2

1

FOXJ1

forkhead box J1

2

0

SFN

stratifin

2

1

G1P3

interferon alpha-inducible protein

2

0

TACSTD2

tumor associated calcium signal transducer 2

2

1

GPX3

glutathione peroxidase 3

2

0

UBE2C

ubiquitin conjugating enzyme E2C

2

1