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Table 1 List of 86 upregulated genes (Meta-UP) derived from literature meta-analysis. Only genes reported at least twice in the 20 publications reviewed were considered. The total numbers of reported upregulated (U) and downregulated (D) genes are provided. Rows in bold indicate protein products that are autoantigens, either reported in the literature or in the SEREX-ovarian dataset.

From: Linking the ovarian cancer transcriptome and immunome

Symbol Gene Name (short) U D Symbol Gene Name (short) U D
MUC1 mucin 1, transmembrane 7 1 H2AFZ H2A histone family, member Z 2 0
FOLR1 folate receptor 1 5 0 HIST1H2AC histone 1, H2ac 2 0
KLK7 kallikrein 7 5 0 HIST1H2BD histone 1, H2bd 2 0
TACSTD1 tumor assoc. calcium signal transducer 1 6 1 HMGB1 high mobility group box 1 2 0
CD47 CD47 antigen 5 1 HP hyptoglobin 2 0
CLDN4 claudin 4 5 1 HSPCA heat shock 90 kDa protein 1, alpha-like 3 2 0
CP ceruloplasmin 4 0 IGLL1 immunoglobulin lambda-like polypeptide 1 2 0
CRABP1 cellular retinoic acid binding protein 1 4 0 ITGB8 integrin beta 8 2 0
KLK6 kallikrein 6 5 1 JAG2 jagged 2 2 0
PRAME preferentially expressed antigen in melanoma 4 0 KLK5 kallikrein 5 2 0
WFDC2 WAP four disulfide core domain 2 4 0 KLK8 kallikrein 8 2 0
APOE apolipoprotein E 3 0 KRT8 keratin 8 2 0
CD24 CD24 antigen 4 1 LCN2 lipocalcin 2 3 1
CD9 CD9 antigen 3 0 LOC389831 hypothetical gene supported by AL713796 2 0
CKS1B CDC28 protein kinase regulatory subunit 1B 3 0 LU lutheran blood group 2 0
HLA-DPB1 MHC class II, DP beta 1 3 0 MAL Mal, T-cell differentiation protein 3 1
KRT18 keratin 18 3 0 MAL2 Mal, T-cell differentiation protein 2 2 0
PRKCI protein kinase C 3 0 MEIS1 Meis 1, myeloid ecotropic viral integration site 2 0
SLPI secretory leukocyte protease inhibitor 4 1 MP14 matrix metalloprotease 14 2 0
SPINT2 serine protease inhibitor 3 0 MSLN mesothelin 2 0
ADAMTS5 disintegrin-like, metalloprotease 2 0 MYCl1 V-myc myelocytomastosis viral oncogene 2 0
ANK3 ankyrin 3 2 0 PAX8 paired box gene 8 3 1
ATF3 activating transcription factor 3 2 0 PEA15 phosphoprotein enriched in astrocytes 15 2 0
BARD1 BRCA1 associated RING domain 1 2 0 PRKCBP1 protein kinase C binding protein 1 2 0
BCL2L1 Bcl-2 like 1 2 0 PRKCH protein kinase C 2 0
BMP7 bone morphogenetic protein 1 3 1 S100A1 S100 calcium binding protein A1 3 1
CD44 CD44 antigen 2 0 SCGB2A1 secretoglobin family 2A member 1 2 0
CKB creatine kinase, brain 2 0 SCNN1A sodium channel, non-voltage gated 2 0
CLU clusterin 2 0 SDC4 syndecan 4 2 0
COL5A1 collagen type V alpha 1 2 0 SIAHBP1 fuse binding protein interacting repressor 2 0
COL9A2 collagen type IX alpha 2 2 0 SLC7A5 solute carrier family 7, member 5 2 0
CRABP2 cellular retinoic acid binding protein 2 2 0 SOX9 SRY-box 9 2 0
D2S448 melanoma associated gene 2 0 SPON1 spondin 1, extracellular matrix protein 2 0
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1 2 0 VEGF vascular endothelial growth factor 2 0
EDD E3 identified by differential display 2 0 CLDN3 claudin 3 2 1
EFNA1 ephirin A1 3 1 IGKC immunoglobulin kappa constant 2 1
ELF3 E74 like factor 3 2 0 KLK10 kallikrein 10 2 1
EYA2 eyes absent homolog 2 (Drosophila) 2 0 KRT19 keratin 19 2 1
FLJ20171 hypothetical protein FLJ20171 2 0 NMU neuromedin U 2 1
FLT1 fms-related tyrosine kinase 1 2 0 PTPRF protein tyrosine phosphatase, receptor type, F 2 1
FOXJ1 forkhead box J1 2 0 SFN stratifin 2 1
G1P3 interferon alpha-inducible protein 2 0 TACSTD2 tumor associated calcium signal transducer 2 2 1
GPX3 glutathione peroxidase 3 2 0 UBE2C ubiquitin conjugating enzyme E2C 2 1