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Table 1 Computational costs in the STAT5 case study (in seconds) for 0% and 10% noise to signal ratio, respectively.

From: Hybrid optimization method with general switching strategy for parameter estimation

Simulated data with 0%/10% noise

Box Size

SS

MS

SRES

Hybrid

5

65/80

140/155

30/46

9/10

10

86/90

317/453

34/55

10/11

100

141/170

950/1095

58/80

17/22

  1. The CPU time is normalized using the Linpack benchmark table and is in case of the multistarts of the single shooting (SS) and multiple-shooting (MS) method the sum over all restarts. Increased robustness of MS results in substantially higher computational cost compared to SS. The hybrid is about 3–4 times faster than SRES manifesting the advantage of the proposed method.
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BMC Systems Biology

ISSN: 1752-0509

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