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Figure 3 | BMC Systems Biology

Figure 3

From: The dynamics and efficacy of antiviral RNA silencing: A model study

Figure 3

Effect of RNA silencing on viral growth. Four qualitative different outcomes of viral growth and silencing. (A) and (B) Bifurcation diagrams for increasing silencing strength. For varying silencing strength the number of plus-strand RNAs 100 hours post infection is shown. Black lines indicate plus-strand RNA, violet lines the number of virions produced, and cyan lines the total number of siRNAs. In the filled area a single peak or multiple oscillations of the number of plus-strand RNAs or the number of siRNAs occur. (A) Dicer cleaves dsRNA and (B) Dicer cleaves ssRNA. (C)-(F) show typical timeseries of behavior in the four regions for c d = 2, c d = 6, c d = 8 and c d = 10. Timeplots show plus-strand RNA (black); minus-strand RNA (red); total number of virions (violet); free siRNA (cyan); free RISC (orange); active RISC (green). Virions can only be formed when virus levels are sufficiently high.

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