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Figure 3 | BMC Systems Biology

Figure 3

From: An ultrasensitive sorting mechanism for EGF Receptor Endocytosis

Figure 3

Steady-State behaviour of internalized receptors. Plotted are steady-state values of Ri_cde (blue) and Ri_cie (green) as a function of EGF-stimulation (EGF0). An ultrasensitive response of CIE-internalization with respect to EGF occurs if R0 > CDE0 (B) or R0 > CDE0+CIE0 (C), but not if R0 < CDE0 (A). In (B) and (C), when EGF0 exceeds the amount of CDE0, CIE-internalization switches on abruptly, with a maximal response if (CDE0+CIE0) < min{CIE0, R0} (C). In all three cases CDE0 = 1.0, CIE0 = 1.0 and (A) R0 = 0.8, (B) R0 = 1.3 and (C) R0 = 2.4.

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