Figure 5

Automatic SNP selection to score Insig1 → Dhrc7 and Insig1 → Fdft1 in female and male mouse livers. These robustness plots show how the LEO.NB scores (y-axis) depend on sets of automatically selected SNP markers (x-axis). Here we use the default SNP selection method: combined greedy and forward stepwise method. Step K corresponds to choosing the top K greedy and top K forward selected SNPs for each trait. Since the greedy and the forward SNP selection may select the same SNPs, step K typically involves fewer than 2K SNPs per trait. Figures (a, b, top row) and (c, d) correspond to female and male BxH mice, respectively. Figures (a) and (c) report the results for edge Insig 1 → Dhrc 7 in female and male mouse livers, respectively. Figures (b) and (d) report the analogous results for Insig 1 → Fdft 1. NEO robustly retrieves the known causal relationship between these genes.