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Figure 6 | BMC Systems Biology

Figure 6

From: Using genetic markers to orient the edges in quantitative trait networks: The NEO software

Figure 6

Fsp27 is a causal driver of a biologically important co-expression module. Prior work using mouse liver expression data found the 'blue' co-expression module to be biologically important [7]. Here we used automatic SNP selection to determine whether Fsp27 is causal of the blue module gene expression profiles. The expression profiles of the blue module were summarized by their first principal component (referred to as module eigengene). The blue module eigengene MEblue can be considered as the most representative gene expression profile of the blue module. The figure shows the results of a robustness analysis regarding LEO.NB(Fsp 27 → MEblue) (y-axis) with respect to different choices of genetic markers sets (x-axis). Both LEO.NB.CPA and LEO.NB.OCA scores show that the relationship is causal, i.e. the Fsp 27 is upstream of the blue module expressions.

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