Figure 6

Follow through of signalling pathways stimulated by IFNG (6a) and FASLG (6b). The signalling events following the input signals of IFNG and FASLG have been highlighted on the entire map in lilac and orange, respectively. The nodes activated or directly affected by FASLG or IFN-gamma binding to their receptors are coloured and the interaction edges and gates are also highlighted. Nodes and edges not directly downstream of the FASLG or IFNG signalling are shown in grey. This figure demonstrates inputs into the pathway can clearly be followed to the expected outcome events. In the case of IFNG-input, gene transcription is the resulting event, and in the case of FASLG, apoptosis. Furthermore these examples clearly depict the interactions of the pathway can be followed logically and do not result in unexpected crosstalk.